anti-cancer agent — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60024	CFT7455	Cemsidomide	Ligand for E3 Ligase
	CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZ...		Ligand for E3 Ligase
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T10342	Antitumor agent-2		Others
	Antitumor agent-2 has anti-inflammatory and anti-tumor activity and can be used to study cancer.		Others
T60852	Anticancer agent 46
	Anticancer agent 46 is a potent anti-cancer agent, showing anti-proliferative activity in cellular assays, with an IC50 of 0.986 μM against MGC803 cells.
T5538	DC661		Apoptosis , Autophagy
	DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.		Apoptosis , Autophagy
T28475	Pyrazoloacridine	PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934	Apoptosis , Topoisomerase
	Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.		Apoptosis , Topoisomerase
T9104	TJ191		Apoptosis
	TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.		Apoptosis
T6S1255	Ophiopogonin-D		ROS
	Ophiopogonin D(OPD) significantly inhibited the in vitro and in vivo growth of prostate cells via RIPK1, OPD may be developed as a potential anti-prostate cancer agent.		ROS
T5822	BTR-1	5-Benzylidene-3-ethyl rhodanine	Apoptosis
	5-Benzylidene-3-ethyl rhodanine(BTR-1 (5-Benzylidene-3-ethyl rhodanine)) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.		Apoptosis
T6S1027	Tussilagone		Others
	1. Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1. 2. Tussilagone has anti-cancer activity, might be a potential chemotherapeutic agent for the prevention and treatment of human co...		Others
T9715	Aplidine		SARS-CoV , DNA/RNA Synthesis
	Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM).		SARS-CoV , DNA/RNA Synthesis
T3870	Cyasterone	Cyasteron	Apoptosis , EGFR
	Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.		Apoptosis , EGFR
T16961	Supinoxin	RX-5902	Apoptosis , DNA/RNA Synthesis
	Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...		Apoptosis , DNA/RNA Synthesis
TN1727	Helichrysetin		Apoptosis , HIV Protease
	Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.		Apoptosis , HIV Protease
T4S1637	Gamma-Mangostin	Normangostin	Others , 5-HT Receptor
	1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...		Others , 5-HT Receptor
T39595	Disitamab vedotin	RC 48,RC-48,RC48	EGFR
	Disitamab vedotin (RC-48) is an antibo-active molecular conjugate (ADC) containing a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) that binds to the cytotoxic agent MMAE via a degradable lin...		EGFR
T72048	CDK8-IN-12		GSK-3 , CDK
	CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showe...		GSK-3 , CDK
T2787	Picroside I	6'-Cinnamoylcatalpol	MMP , STAT
	Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug ...		MMP , STAT
T3867	Alpinetin	(-)-alpinetin	BCL , PPAR
	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...		BCL , PPAR
T7028	Licochalcone C	LICOCHALCONEC	Phosphatase , Antioxidant , Glucosidase
	Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activit...		Phosphatase , Antioxidant , Glucosidase